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Amazon.com customers are giving "The Pathological Protein" five-star treatment. Some examples (collected from Amazon's U.S., Canada and U.K. sites--thanks to the reviewers!):
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5 out of 5 stars
Best synopsis so far, August 15, 2003
Reviewer: Bill Tillier from Calgary, Alberta Canada
Yam presents a very detailed yet very interesting account of the Prion situation. This is a fairly complex topic to tackle but it is done in a stepwise way that takes the reader along with it. The account seems even-handed and I think the science is very sound. Much better than the current but disappointing "How the Cows turned mad" by Maxime Schwartz.
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5 out of 5 stars
Easily the best book of its kind
7 October, 2003
Reviewer: Stuart MacDiarmid from Wellington New Zealand
Philip Yam's book The Pathological Protein is easily the best book of its kind. Written in clear, simple language for the non-specialist audience, The Pathological Protein is a thoroughly comprehensive, concise and, above all, scientifically accurate review of BSE and related diseases. Yam has been writing and editing for Scientific American since 1989 and this, his first book, demonstrates the high standard to which all science writers ought to aspire.
The first chapter of The Pathological Protein describes, from a very human perspective, the effects of variant Creutzfedt-Jakob disease on one victim, 19 year-old Stephen Churchill, and his family. From this tragedy, Yam then goes on to review the history of CJD and the mysterious diease 'kuru', which reached epidemic proportions amongst the Fore people of Papua-New Guinea because of their cannibalistic funerary rites. After discussing the hereditary transmissible spongiform encephalopathies (TSEs) of humans, outlines what is known of the TSEs of animals. Philip Yam's reviews of scrapie, BSE, transmissible mink encephalopathy and chronic wasting disease are up-to-date, interesting, and extremely readable.
There is an interesting episode related in the book. Carlton Gajdusek had been searching, unsuccesfully, for the cause of kuru. William Hadlow, and American scrapie researcher on a secondment to the United Kingdom, visited the Wellcome Medical Museum in London to look at a display on kuru that Gajdusek had prepared. It was Hadlow who first noticed the very close resemblance between kuru and scrapie. The similarities in epidemiologic features, general clinical pattern and the neurohistologic changes led him to the realisation that these diseases were probably mmebers of the same family. As a result of Hadlow's insight transmission experiments were started which, eventually, led to our current understanding of the TSEs
This book covers the hypotheses for the origins of BSE, the evidence for the link between BSE and vCJD, current methods and problems of diagnosis of the TSEs, and the search for cures. Philip Yam clearly is thoroughly versed in the scientific literature of the TSEs, but also interviewed a broad range of scientists, consumers advocates and regulators. So, he knows what he is writing about, and this is made evident by the clarity and accuracy of his explanations. Although there is no 'dumbing down' of a difficult and complex subject, the author has written a book which makes his subject easily accessible to the non-specialist reader. The book is referenced, well indexed, has a useful glossary and also suggests sources for further information, including the more useful web sites and organisations providing suport and help for families of CJD victims. While the book is written for the interested lay person, I would have no hesitation in recommending Philip Yam's The Pathological Protein to veterinarians and colleagues who want an interesting, thorough and current review of these fascinating diseases.
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5 out of 5 stars A view from a relative of a vCJD victim
18 September, 2003
Reviewer: Mr Graham Steel from Scotland, UK
I was first alerted to this book about 3 months ago. I have read most of the book now. The reporting within the book is remarkably accurate and up to date. It pulls in so much information from across the world of the, still, many uncertainties re. TSE issues.
I have sadly learned yesterday of another vCJD victim (alive) in the US. The individual has never been to the UK. The relavence of this book is of upmost importance if we are to unravel the many unknowns of CJD/BSE and also CWD.
I lost my brother to vCJD in 1999. I am currently Vice-Chair of Human BSE Foundation here in the UK. In essence, we are a support group. We recently travelled to the US, to "tell or story" at a CJD Conference. We are now working with many other similar Organisations to tackle these outstanding issues. We must campaign globally, if we are so stand any chance in our campaign.
We therefore welcome the importance of The Pathelogical Protien for a number of reasons. The more that people learn accurately about all of this the better for us all.
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